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. 2015 Oct 20;44(2):669–682. doi: 10.1093/nar/gkv1080

Figure 1.

Figure 1.

The Slx4-Rtt107 complex is required for checkpoint adaptation to one irreparable DSB and uncapped telomeres. (A) Schematic illustration of the HO-cut checkpoint-adaptation assay. (B) Graph shows the percentage of adapted cells for each mutant 24 h after plating on galactose containing medium to induce one irreparable HO cut. Values are the mean of three independent experiments ± standard deviation. (C) Rad53 phosphorylation analysis by Western Blot in JKM179 derivative strains after HO induction. (D) Adaptation assay in cdc13–1 derivative strains. Graph shows the percentage of adapted cells after 24 h at 37°C. Values are the mean of three independent experiments ± standard deviation. (E) Rad53 phosphorylation analysis by Western blot in cdc13–1 derivative strains after telomere uncapping at 37°C.