Fig. 6. Distributions (PDF) of restraint intensities for different chemical shifts of ubiquitin.

When combining data from different experiments, metainference automatically determines the weight of each piece of information. In the case of ubiquitin, the NH and HN chemical shifts were determined as the less reliable data and thus were downweighted in the construction of the ensemble of models. From this procedure it is not possible to determine whether these two specific data sets have a higher level of random or systematic noise, or whether instead the CAMSHIFT predictor (38) is less accurate for these specific nuclei.