Table 3.
Significant associations between carrier frequencies of HLA alleles and “all cHL” and EBV‐stratified subgroups in unadjusted analyses
| HLA allele | Cases vs. controls | EBV+ cases vs. controls | EBV− cases vs. controls | EBV+ cases vs. EBV‐ cases |
|---|---|---|---|---|
| OR (CI), p value | OR (CI), p value | OR (CI), p value | OR (CI), p value | |
| A*01:01 | 1.4 (1.1, 1.8), 0.020 | 3.1 (2.1, 4.6), 9.7e‐9 | 1.0 (0.7, 1.3), 0.85 | 3.2 (2.2, 4.7), 4e‐9 |
| C*07:01 | 1.5 (1.1, 2.0), 0.0045 | 2.5 (1.7, 3.6), 5.8e‐6 | 1.2 (0.9, 1.7), 0.24 | 2.0 (1.4, 3.0), 0.00033 |
| C*07:02 | 1.3 (1.0, 1.8), 0.055 | 0.7 (0.4, 1.1), 0.092 | 1.7 (1.3, 2.4), 0.00072 | 0.4 (0.2, 0.6), 1.8e‐5 |
| C*06:02 | 1.0 (0.7, 1.4), 0.81 | 1.6 (1.0, 2.5), 0.039 | 0.7 (0.5, 1.1), 0.11 | 2.2 (1.4, 3.6), 0.00081 |
| B*08:01 | 1.6 (1.2, 2.2), 0.0014 | 3.0 (2.0, 4.4), 8.9e‐8 | 1.2 (0.9, 1.7), 0.25 | 2.4 (1.6, 3.6), 9e‐6 |
| B*07:02 | 1.4 (1.0, 1.9), 0.029 | 0.7 (0.4, 1.1), 0.098 | 1.8 (1.3, 2.5), 0.00023 | 0.4 (0.2, 0.6), 7.3e‐6 |
| B*37:01 | 1.4 (0.7, 2.7), 0.31 | 2.9 (1.4, 6.1), 0.0038 | 0.8 (0.4, 1.7), 0.55 | 3.7 (1.7, 8.2), 0.00073 |
| DRB1*03:01 | 1.5 (1.1, 2.0), 0.012 | 2.3 (1.5, 3.5), 6.4e‐5 | 1.2 (0.9, 1.7), 0.29 | 1.9 (1.3, 2.9), 0.0014 |
| DRB1*15:01 | 1.2 (0.9, 1.7), 0.17 | 0.5 (0.3, 0.8), 0.0021 | 1.7 (1.3, 2.4), 0.00083 | 0.3 (0.2, 0.4), 1.5e‐8 |
| DRB1*07:01 | 0.5 (0.4, 0.8), 0.00075 | 0.7 (0.4, 1.1), 0.15 | 0.5 (0.3, 0.7), 0.00027 | 1.5 (0.9, 2.5), 0.14 |
| DQB1*06:02 | 1.5 (1.1, 2.2), 0.021 | 0.3 (0.1, 0.7), 0.0020 | 2.4 (1.6, 3.5), 1.6e‐5 | 0.1 (0.1, 0.3), 1.7e‐8 |
EBV+ cases: EBV‐positive cHL cases; EBV− cases: EBV‐negative cHL cases; vs: versus; OR: odds ratio; CI: confidence interval. Results in bold are significant after correction for multiple testing; results in italics have p values < 0.05. Alleles are included in the table only if the p value for one of the outcomes was significant after correction for multiple testing.