Table 4.
Final model for EBV‐positive Hodgkin lymphoma, adjusted for sex and age group
| Variable | PPA | OR (95% CI) | p‐values |
|---|---|---|---|
| HLA‐A*01:01 additive# | 84% | 2.49 (1.75, 3.59) | 2.5 × 10−7 |
| HLA‐A*02:01 additive# | 11% | 0.97 (0.66, 1.42) | 0.89 |
| HLA‐B*37:01 carrier | 66% | 2.58 (1.13, 6.04) | 0.024 |
| HLA‐DRB1*15:01 carrier | 59% | 0.45 (0.26, 0.75) | 0.0019 |
| HLA‐DPB1*01:01 carrier◊ | 88% | 0.22 (0.06, 0.65) | 0.004 |
Bayesian variable selection modeling was performed on EBV‐positive Hodgkin lymphoma cases versus controls, with inclusion of 44 HLA alleles and three selected MHC SNPs; alleles with a posterior probability of association (PPA) ≥ 50% were selected and refitted in a Firth logistic regression model to generate ORs and CIs. #, adjustment variable, not subject to variable selection; ◊, data derived from analysis of smaller data set.