Table 5.

Final model for EBV‐negative cHL, adjusted for sex and age group

Variable	PPA	OR (95% CI)	p‐Value
HLA‐B*15:01 carrier	60%	1.81 (1.10, 3.02)	0.020
rs6903608 C homozygote	95%	3.61 (2.16, 6.25)	4.5 × 10−7
HLA‐DRB1*03:01 homozygote	67%	5.14 (1.80, 17.56)	0.0018
HLA‐DQB1*03:03 carrier◊	70%	3.22 (1.26, 8.36)	0.015

Bayesian variable selection modeling was performed on EBV‐negative Hodgkin lymphoma cases versus controls, with inclusion of 44 HLA alleles and three selected MHC SNPs; alleles with a posterior probability of association (PPA) ≥ 50% were selected and refitted in a Firth logistic regression model to generate ORs and CIs. ◊ data derived from analysis of smaller dataset.