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. 2015 Dec 18;63(2):418–427. doi: 10.1002/hep.28322

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© 2015 The Authors. HEPATOLOGY published by Wiley Periodicals, Inc., on behalf of the American Association for hte Study of Liver Diseases.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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DEPDC5 rs1012068 is associated with cirrhosis in European subjects with chronic HCV infection. (A) Genotype distribution of DEPDC5 rs1012068 in the discovery cohort. (B) Genotype distribution of DEPDC5 rs1012068 in the cross‐sectional validation cohort. The validation cohort consisted of subjects from the Leipzig and Bern cohorts pooled together. Carriers of the G allele also had a higher risk of cirrhosis (OR, 1.46; 95% CI, 1.04‐2.04; P = 0.027 after pooling together the discovery and the validation cohorts and adjusting for age, sex, and recruitment center). The exact frequencies are shown in Supporting Table 3.