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. 2015 Dec 18;63(2):418–427. doi: 10.1002/hep.28322

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© 2015 The Authors. HEPATOLOGY published by Wiley Periodicals, Inc., on behalf of the American Association for hte Study of Liver Diseases.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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DEPDC5 rs1012068 is associated with fibrosis progression in Europeans with chronic HCV infection. The genotype distribution of DEPDC5 rs1012068 is shown in the cross‐sectional (A) and in the prospective (B) validation cohorts. The cross‐sectional validation cohort consisted of subjects from Leipzig and Bern cohorts pooled together. Carriers of the G allele also had a higher risk of moderate/severe fibrosis (OR, 1.46; 95% CI, 1.04‐2.04; P = 0.027 after adjusting for age, sex, and recruitment center). The association between DEPDC5 rs1012068 and FPR was calculated by multivariate generalized linear models under an additive genetic model (see Table 2 for further details).