Table 1.
Demographic and Clinical Characteristics of the Cohorts
| Discovery Cohort | Validation Cohort | |||
|---|---|---|---|---|
| Milan | Leipzig | Bern | Milan Prospective | |
| N | 477 | 268 | 147 | 247 |
| Age, years | 63 ± 12 | 52 ± 12 | 48 ± 11 | 47 ± 11 |
| Sex | ||||
| Men | 317 (67) | 130 (49) | 93 (63) | 129 (52) |
| Women | 160 (33) | 138 (51) | 54 (37) | 118 (48) |
| Alcohol consumption | ||||
| None/milda | 433 (91) | 108 (77) | 110 (75) | 247 (100) |
| At‐riskb | 44 (9) | 32 (23)c | 37 (25) | 0 (0) |
| Liver fibrosis stage | ||||
| F0‐F1 | 177 (37) | 105 (39) | 68 (46) | 157 (64) |
| F2‐F4 | 300 (63)d | 163 (61) | 79 (54) | 90 (36) |
| Cirrhosis | 300 (63) | 72 (27) | 37 (25) | — |
| HCC | 150 (31) | 50 (19) | 8 (5) | 0 (0) |
Data are presented as the mean ± standard deviation or as n (%).
a
Defined as 0‐20 g/day for women and 30 g/day for men.
b
Defined as >20 g/day for women and >30 g/day for men.
c
Data on alcohol intake were not available in 128 subjects (48%).
d
All subjects in this cohort had stage F4 fibrosis.