Table 1.

Clinicopathological characteristics of cancer and adenoma cases

	High‐methylation CRC	SSA/P	TSA	p‐values
				CRC vs. SSA/P	CRC vs. TSA	SSA/P vs. TSA
No. of cases	17	45	14
Sex (male/female)	5/12	23/22	11/3	0.16	0.01a	0.12
Age (years)	69.0 ± 8.9	64.2 ± 11.0	61.5 ± 8.0	0.11	0.01a	0.39
Tumor location				0.61	0.0003a	<0.0001a
Proximal (C/A/T)	15 (4/10/1)	42 (12/24/6)	2 (0/1/1)
Distal (D/S/R)	2 (1/1/0)	3 (1/1/1)	12 (1/8/3)
Tumor size (mm)	74.5 ± 31.3	27.3 ± 7.8	23.4 ± 15.4	<0.0001a	<0.0001a	0.21
Genetic aberration, n (%)
KRAS mutation(+)	3 (18)	2 (4)	7 (50)	0.12	0.12	0.003a
BRAF mutation(+)	12 (82)	36 (80)	6 (43)	0.50	0.16	0.02a
Dysplastic change, n (%)				n.a.	n.a.	0.014a
No dysplastic change	n.a.	18 (40)	0 (0)
Low‐grade dysplasia	n.a.	21 (47)	12 (86)
High‐grade dysplasia	n.a.	6 (13)	2 (14)

For comparison of tumor location, tumors were classified into two locations: proximal colon, including cecum (C), ascending (A) and transverse (T) colon and distal colon, including descending (D) and sigmoid (S) colon and rectum (R). The tumor size was recorded as the maximum diameter of the extirpated specimen. p‐values were analyzed by Fisher's exact test or Student's t‐test for age and tumor size.

^a p < 0.05.

Abbreviation: n.a., not applicable.