. Author manuscript; available in PMC: 2016 Nov 1.

Published in final edited form as: Bioorg Med Chem Lett. 2015 Jun 23;25(21):4834–4837. doi: 10.1016/j.bmcl.2015.06.066

Table 3.

In vivo pharmacokinetic properties of selected cruzain inhibitors.

Compound	Route	Dose (mg/kg)	Cmax (ng/mL)	AUC (ng*h/mL)	T_1/2	CL (mL/min/kg)	Vss (L/kg)	%F
4	IV	10	4133	4673	2.95	36.2	4.2
	PO	40	833	3860	3.34			21
8	IV	10		8706	4.2	19	5.4
	PO	40		8096	3			23
11	IV	10	-	9613	5.67	16.6	6.5
	PO	40	1228	6566	3.41			19.1
21	IV	10		5370	3.04	30.7	4.19
	PO	40		8107	2.32			37