Figure 1.

NT transiently increases the AP firing frequency of dentate gyrus GCs assessed by perforated patches. (A) APs recorded from a dentate gyrus GC before, during, and after the application of NT (0.5 µm). (B) Time course of AP firing frequency pooled from 7 cells. (C) Concentration–response curve of NT. The numbers in the parentheses were numbers of cells recorded at each concentration. (D) Bath application of the active fragment of NT (NT8-13) at the concentration of 0.5 µm transiently enhanced the AP firing frequency, whereas application of the inactive fragment (NT1-8) at the same concentration failed to augment the AP firing frequency.