Table 1.

Loci newly associated with kidney function-related traits

rsIDa	Chr.	Position (bp)	Band	Gene	A1/A2b	Freq.c	GWAS meta-analysis		Replication study		Combined study
							β (SE)d	P	β (SE)d	P	β (SE)d	P
Blood urea nitrogen (n = 39,717 for GWAS meta-analysis, n = 17,461 for replication)
rs2049805	1	153461604	1q22	MTX1-GBA	T/C	0.17	0.0072 (0.0013)	1.9 × 10−8	0.0072 (0.0017)	2.3 × 10−5	0.0072 (0.0010)	1.8 × 10−12
rs11123170	2	113695411	2q13	PAX8	G/G	0.35	0.0059 (0.0010)	2.4 × 10−9	0.0035 (0.0014)	0.014	0.0051 (0.0008)	3.3 × 10−10
rs16853722	3	170633326	3q26	MECOM	C/T	0.29	0.0059 (0.0010)	1.3 × 10−8	0.0072 (0.0014)	2.7 × 10−7	0.0064 (0.0008)	2.7 × 10−14
rs10275044	7	1240371	7p22	UNCX	T/A	0.34	0.0079 (0.0015)	1.3 × 10−7	0.0053 (0.0019)	0.0056	0.0069 (0.0012)	4.3 × 10−9
rs10767873	11	30725254	11p14	MPPED2- DCDC5	C/T	0.69	0.0068 (0.0010)	7.0 × 10−11	0.0068 (0.0014)	1.4 × 10−6	0.0068 (0.0008)	4.5 × 10−16
rs2074356	12	111129784	12q24.13	C12orf51	A/G	0.23	0.0064 (0.0013)	4.4 × 10−7	0.0063 (0.0020)	0.0012	0.0064 (0.0011)	1.8 × 10−9
rs17730281	15	51695240	15q21	WDR72	G/A	0.58	0.0054 (0.0010)	1.5 × 10−8	0.0046 (0.0013)	4.5 × 10−4	0.0051 (0.0008)	3.0 × 10−11
rs11868441	17	56594003	17q23	BCAS3	G/A	0.75	0.0062 (0.0013)	2.1 × 10−6	0.0055 (0.0015)	2.2 × 10−4	0.0059 (0.0010)	2.1 × 10−9
rs6026584	20	56902468	20q13	GNAS	T/C	0.32	0.0055 (0.0011)	7.1 × 10−7	0.0046 (0.0016)	0.0033	0.0052 (0.0009)	8.8 × 10−9
Serum creatinine (n = 42,257 for GWAS meta-analysis, n = 19,662 for replication)
rs3828890	6	31548648	6p21	MHC region	G/C	0.11	0.0074 (0.0015)	5.3 × 10−7	0.0060 (0.0018)	0.0011	0.0069 (0.0012)	2.6 × 10−9
rs10277115	7	1251721	7p22	UNCX	T/A	0.35	0.0060 (0.0009)	2.2 × 10−10	0.0034 (0.0015)	0.022	0.0052 (0.0008)	4.6 × 10−11
rs963837	11	30705666	11p14	MPPED2- DCDC5	T/C	0.64	0.0036 (0.0007)	7.5 × 10−7	0.0040 (0.0012)	0.0013	0.0037 (0.0006)	3.4 × 10−9
rs671	12	110726149	12q24.2	ALDH2	A/G	0.27	0.0047 (0.0009)	5.0 × 10−8	0.0040 (0.0013)	0.0015	0.0045 (0.0007)	2.8 × 10−10
eGFRcrea (n = 42,451 for GWAS meta-analysis, n = 19,636 for replication)
rs3828890	6	31548648	6p21	MHC region	G/C	0.11	−0.0091 (0.0017)	9.8 × 10−8	−0.0062 (0.0020)	0.0018	−0.0079 (0.0013)	1.2 × 10−9
rs10277115	7	1251721	7p22	UNCX	T/A	0.35	−0.0066 (0.0011)	7.3 × 10−10	−0.0039 (0.0016)	0.014	−0.0058 (0.0009)	1.0 × 10−10
rs963837	11	30705666	11p14	MPPED2- DCDC5	T/C	0.64	−0.0041 (0.0008)	6.3 × 10−7	−0.0048 (0.0013)	3.8 × 10−4	−0.0043 (0.0007)	1.1 × 10−9
Uric acid (n = 21,417 for GWAS meta-analysis, n = 11,657 for replication)
rs889472	16	78203490	16q23	MAF	C/A	0.57	0.0758 (0.0136)	2.8 × 10−8	0.0584 (0.0227)	0.010	0.0711 (0.0117)	1.1 × 10−9

Chr., chromosome; SE, standard error, Freq., frequency.

^aSNPs in the newly identified loci associated with kidney function-related traits.

^bThe allele that increased blood urea nitrogen, serum creatinine or uric acid concentration or that decreased eGFRcrea was defined as allele 1 (Al) and is indicated on the basis of the forward strand of NCBI Build 36.

^cFrequency of allele 1 in the GWAS meta-analysis.

^dEffect size of allele 1 on common log-transformed values of blood urea nitrogen or serum creatinine concentration, eGFRcrea or non-transformed values of uric acid concentration.