Table 2.

Process Networks most enriched in genes up 3-fold (p<0.05) in OVE-GFP podocytes.^a

Rank	Process Network	Network Objects Increased 3X / Total Network Size	P- Value	Network Objects Increased 3X
1	Inflammation_Complement system	7/73	0.00	Clusterin, C5AR, C3dg, C3, iC3b, C3a, C3b
2	Cell adhesion_Cell junctions	7/162	0.00	Occludin, Desmoglein 2, Claudin-7, Keratin 18, Keratin 8/18, E-cadherin, Keratin 8
3	Cytoskeleton_Intermediate filaments	5/81	0.00	NEFL, NEFM, Keratin 18, Keratin 8/18, Keratin 8
4	Inflammation_Innate inflammatory response	7/181	0.00	C5AR, β-defensin 1, IL-1F6, C3, C3a, C3b, COX-2 (PTGS2)
5	Chemotaxis	7/137	0.00	Gα(q)-GPCRs, Gα(i)-GPCRs, C5AR, Osteopontin, CXCL1, CXCL16, CXCL2
6	Immune response Phagocytosis	6/222	0.00	APOB, C3, C3b, C3dq, iC3b, LDL
7	Development Neurogenesis Axonal Guidance	6/230	0.02	Calcyclin, NEFL, NEFM, Neuropilin-1, Semaphorin 3C, SPOCK2
8	Immune response Phagosome in antigen presentation	6/243	0.02	C3, C3dq, Cathepsin S, HLA-DQA1, iC3b, MHC classII
9	Development Cartilage development	3/66	0.02	Activin beta A, Collagen XII, MGP
10	Cell adhesion_Leucocyte chemotaxis	6/205	0.03	Gα(q)-GPCRs, Gα(i)-GPCRs, MHC class II, CXCL1,CXCL16

^a Process Networks are network models created by Metacore of main cellular processes based on GO-processes and pathway maps. The P-value column indicates the probability calculated by Metacore software of obtaining the degree of overlap between the set of objects in the Network and the set of OVE-GFP genes increased 3 fold.