Table 2.
Changes in “symptom related” 24 h pH monitoring indices from baseline to follow-up examination by study group
|
Baseline |
Follow up |
2-wk change |
P-value (treatment x time) | ||||
| Mean | (SD) | Mean | (SD) | Mean change | (95%CI) | ||
| Symptom index for reflux (SI) | 0.0483 | ||||||
| Formula A (n = 16) | 39.7 | -26.2 | 21.6 | -14.5 | -18.23 | (-31.8 to -4.57)3 | |
| Formula B (n = 15) | 24.5 | -27.2 | 19.7 | -20.8 | -5.21 | (-19.5 to 9.03) | |
| Formula C (n = 16) | 27.7 | -20.6 | 33.7 | -24.8 | 6.49 | (-7.39 to 20.4) | |
| P value (Treatment effect) | 0.213 | 0.119 | |||||
| Symptom association probability1 | 0.096 | ||||||
| Formula A (n = 16) | 87.4 | -25.2 | 49.5 | -42.5 | -37.93 | (-64.6 to -11.3)3 | |
| Formula B (n = 15) | 54.6 | -47.3 | 58.7 | -40.2 | 3.82 | (-24.1 to 31.7) | |
| Formula C (n = 16) | 82.9 | -33.8 | 57.8 | -38.3 | -24.8 | (-52.0 to 2.37) | |
| P value (Treatment effect) | 0.031 | 0.762 | |||||
| Percentage of acid refluxes2 (%) | 0.067 | ||||||
| Formula A (n = 16) | 39.8 | -26.1 | 22.6 | -15.0 | -17.23 | (-30.8 to -3.66)3 | |
| Formula B (n = 15) | 24.6 | -27.3 | 19.4 | -20.8 | -5.53 | (-19.7 to 8.65) | |
| Formula C (n = 16) | 27.7 | -20.4 | 33.3 | -25.3 | 5.93 | (-7.89 to 19.8) | |
| P value (Treatment effect) | 0.21 | 0.152 | |||||
| Percentage of all reflux (%) | 0.0143 | ||||||
| Formula A (n = 16) | 47.9 | -22.3 | 31.0 | -18.1 | -16.93 | (-31.3 to -2.28)3 | |
| Formula B (n = 15) | 35.1 | -23.6 | 36.8 | -28.7 | 1.78 | (-13.3 to 16.9) | |
| Formula C (n = 16) | 33.7 | -22.3 | 48.2 | -28.8 | 14.4 | (-0.28 to 29.2) | |
| P value (Treatment effect) | 0.167 | 0.201 | |||||
1
Probability that symptom and reflux are not associated solely by chance;
2
Percentage of acid refluxes out of the total number of refluxes occurring during the 24 h monitoring;
3
Indicate statistical significant findings. The “symptom related” 24 h pH monitoring indices include those indices recorded during the 24 h pH monitoring procedure requiring caregiver’s interference by pressing the “event button”. Adjustment was made for the average volume of milk consumed by infants per day during the intervention period.