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Comparison of adverse effects of oral ibuprofen and paracetamol[3]
| Oral ibuprofen | Oral paracetamol | |
| Renal side effects | +/- | - |
| NEC | + | - |
| Spontaneous intestinal perforation | + | - |
| Gastrointestinal system bleeding | ++ | - |
| IVH | + | - |
| BPD | +/- | - |
| Alteration of platelet function | + | - |
| Decrease in cerebral blood flow | - | - |
| Hyperbilirubinemia | +/- | - |
| Hypertransaminasemia | - | + |
NEC: Necrotizing enterocolitis; IVH: Intraventricular hemorrhage; BPD: Bronchopulmonary dysplasia.
