Table 1.

Brugada Syndrome Susceptibility Genes.

	Locus	Gene	Ion Channel	% of Probands
BrS1	3p21	SCN5A, Nav1.5	↓ INa	11–28%
BrS2	3p24	GPD1L	↓ INa	Rare
BrS3	12p13.3	CACNA1C, Cav1.2	↓ ICa	6.6%
BrS4	10p12.33	CACNB2b, Cavβ2b	↓ ICa	4.8%
BrS5	19q13.1	SCN1B, Navβ1	↓ INa	1.1%
BrS6	11q13–14	KCNE3, MiRP2	↑ Ito	Rare
BrS7	11q23.3	SCN3B, Navβ3	↓ INa	Rare
BrS8	12p11.23	KCNJ8, Kir6.1	↑ IK-ATP	2%
BrS9	7q21.11	CACNA2D1, Cavα2δ	↓ ICa	1.8%
BrS10	1p13.2	KCND3, Kv4.3	↑ Ito	Rare
BrS11	17p13.1	RANGRF, MOG1	↓ INa	Rare
BrS12	3p21.2-p14.3	SLMAP	↓ INa	Rare
BrS13	12p12.1	ABCC9, SUR2A	↑ IK-ATP	Rare
BrS14	11q23	SCN2B, Navβ2	↓ INa	Rare
BrS15	12p11	PKP2, Plakophillin-2	↓ INa	Rare
BrS16	3q28	FGF12, FHAF1	↓ INa	Rare
BrS17	3p22.2	SCN10A, Nav1.8	↓ INa	16.7%
BrS18	6q	HEY2 (transcriptional factor)	↓ INa	Rare
BrS19	7p12.1	SEMA3A, Semaphorin	↑ Ito	Rare