Figure 1.
The RNA editing core complex catalyzes elementary RNA editing reactions. Direct protein-protein interactions within core complex are depicted by black bars. Roman numerals signify three elementary steps of RNA editing: mRNA cleavage, U-deletion or insertion and mRNA ligation. MP: mitochondrial protein (structural and/or RNA binding components); REX: RNA editing exonuclease; REN: RNA editing endonuclease; REL: RNA editing ligase; RET: RNA editing TUTase; anchor: 5-15-nt long double-stranded region formed by the 5′ portion of the gRNA and pre-edited mRNA.
