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. 2016 Jan 1;6(3):342–356. doi: 10.7150/thno.11918

Figure 2.

Figure 2

In vivo and ex vivo imaging of ICG-labelled m-NC in CT26 tumour-bearing balb/c mice under the influence of magnetic field. Mice were i.v. injected with PBS, ICG or m-NC-ICG, respectively. Magnetic field (MF) was applied by placing a permanent magnet (0.515 T) at one tumour (m-TU) for 1 h. a, Representative whole body in vivo images of mice obtained at 1, 4 and 24 h post-injection. b, Representative ex vivo images of excised organs at 24 h post-injection. c, Ex vivo quantification of fluorescence signals of ICG and ICG-labelled m-NC per gram of tumour at 24 h. d, In vivo quantification of fluorescence signals of ICG per gram of tumour at the magnetically targeted site (m-TU) and the non-magnetically targeted site (TU) of mice at different time points. Tumour accumulation in b was observed with mice injected with m-NC-ICG, but not with free ICG which exhibited high signals in intestine. Quantitative results also showed significantly enhanced uptake in m-TU compared to TU (*p<0.05, **p<0.01, ***p<0.005). Values were expressed as means ± SD (n=3). All images were obtained by IVIS Lumina® III and data were analysed by Living Image® 4.3.1 Service Pack 2 software.