Figure 7.
(A) Histology images of solid tumors. The tissue hemorrhage, DL distribution, and vessel patterns are shown by H&E stain, DLs, and merged (DLs+CD31) images, respectively. The deep-purple color indicates intratumoral hemorrhage stained with H&E in the MD and ND groups. Comparing the locations of DLs and vessels in merged images, DLs only appear near the vessel wall in the EPR group, but express a hazy pattern in the MD and ND groups. (B) Quantification of DL accumulation in solid tumors (* p<0.05, † p<0.01).