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. 2016 Jan 20;6(3):404–417. doi: 10.7150/thno.13478

Figure 3.

Figure 3

In vitro and ex vivo bovine liver HIFU/pH-dual controlled release of DOX. (a) The DOX release curves at different pH levels with or without HIFU exposure. An obvious rise was exhibited at 5 h for HIFU exposure. (b) Digital photos of samples at different time-points (pre exposure, post exposure 30 min, 1 h, 7 h, 19 h) without HIFU exposure (left) and with HIFU exposure (right) in PBS. HIFU exposure group would markedly enhance DOX release against control group due to the solution became redder. (c) DOX fluorescence microscope images of ex vivo bovine liver were obtained by Inverted fluorescence microscope. (d) The quantitative analysis of DOX fluorescence intensity. (e) High Performance Liquid Chromatography (HPLC) images of DOX aqueous solution (20 °C), DOX aqueous solution (80 °C, 15 min) and DOX aqueous solution (80 °C, 30 min).