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. 2016 Jan 20;6(3):404–417. doi: 10.7150/thno.13478

Figure 4.

Figure 4

Dual-mode imaging in vitro and in vivo experiments. (a) B-Mode and contrast enhanced ultrasound (CEUS) imaging of particles before and after HIFU exposure in vitro (gel model) for HMPBs-DOX/PFH (top row), HMPBs-DOX (second row), PFH (third row) and saline only (bottom row). (b-c) Echo Intensity (EI) in B-Mode and CEUS before and after HIFU exposure. Echo intensity value of B-mode in HMPBs-DOX/PFH group was five times higher than other three groups. Similarly, echo intensity value of CEUS in HMPBs-DOX/PFH group was almost ten times higher than other three groups. (d) B-Mode and PA-Mode imaging of particles before and after HIFU exposure in vitro (gel model) for the same groups. (e-f) Echo Intensity (EI) in B-Mode and photoacoustic average value before and after HIFU exposure. The PA intensity value of post-exposure (16.35 ± 1.046 a.u.) was approximately twice as high as the one of pre-exposure (8.901 ± 1.197 a.u.) in HMPBs-DOX/PFH group. (g) B-Mode and photoacoustic imaging of saline and HMPBs-DOX/PFH before and after HIFU exposure in vivo for pre-injection (top row), post-injection (middle row) and after HIFU exposure (bottom row). (h-i) Echo Intensity (EI) in B-Mode and photoacoustic average value before and after HIFU exposure.