Skip to main content
. 2016 Jan 20;6(3):404–417. doi: 10.7150/thno.13478

Figure 5.

Figure 5

Ex vivo HIFU synergistic effect assessment. (a) Schematic 3D illustration of ablation process on bovine livers in vitro. (b) Digital photos of ablated bovine livers exposed to HIFU at 120 W, 150W and 180 W for 5 s after injection of 0.3 mL saline control, HMPBs, DOX, HMPBs-DOX, HMPBs-PFH and HMPBs-DOX/PFH. (c) Typical in vitro B-mode ultrasound images before and after HIFU exposure on degassed bovine livers at 120 W, 150W and 180 W for 5 s. (d) The corresponding necrotic volume after injection of the same samples. The necrotic volume in HMPBs-DOX/PFH group was higher than that in the other four groups (p<0.05). However, there is no significant difference between HMPBs-DOX/PFH group and HMPBs-PFH group (p>0.05). The necrotic volume of HMPBs-DOX/PFH group is at least ten times larger than the volumes of saline group at the same power. (e) Ex vivo temperature were observed by thermodetector in order to illustrating HMPBs-DOX/PFH can generate PFH bubbles using these HIFU ablation parameters.