Figure 8. Model of the multiple roles of Sgo2 during the cell cycle.

During M phase, Sgo2 accumulates at the outer regions of the centromeres, where H3K9me is enriched and recruits CPC for precise chromosome segregation. In interphase, Sgo2 is enriched at the heterochromatin-adjacent region of the subtelomeres, where the levels of the histone modifications such as H3K9me, H3K4me and H3K36me are relatively low. Sgo2 is essential to form the knob structures and to repress both gene transcription and replication, to ensure proper gene expression and replication timing.