Table 2.

Pearson's correlation coefficient (r) values obtained by each cell marker correlated with each of the humoral marker and cytokines ^a

	Pearson's correlation co-efficient (r)
	CD4	CD25	FoxP3	HLA-DR
CIC-c1q	0.04	0.04	0.12	0.06
Anti CCP	0.42	0.48	0.62	0.41
IgG RF	0.07	0.156	0.25	0.1
IgM RF	0.53	0.59	0.73	0.52
Anti-ds DNA	–0.12	–0.18	–0.21	–0.142
TNF-α	–0.23	–0.242	–0.23	0.216
IFN-γ	0.32	0.345	0.46	0.25
IL-10	0.39	0.463	0.59	0.28

The change in the distribution of the Treg subsets was correlated with serologic features of RA. Pearson's correlation coefficient (r) between 0 and 1 demonstrates a positive correlation between the cellular and humoral responses. In overview, data (Table 2) suggest a positive correlation between cellular responses from synovium and early humoral markers. It was observed that a positive correlation exists between IgM RF and expression of all the cellular markers, while a negative correlation existed between anti-ds DNA and expression of investigated molecules. TNF-α shows a negative correlation with FoxP3 expression whereas IL-10 and IFN-γ levels were positively correlated with FoxP3 expression.