Fig. 4a–b.

Total ion chromatograms of the products of the incubation of oligonucleotides with HLM for 12 h a ISI20, b ISIA18. Analytical conditions: chromatographic column, Hypersil Gold C18; mobile-phase composition, 150 mM HFIP/5 mM DMBA and MeOH; gradient elution from 20 % v/v to 45 % v/v MeOH in 10 min; column temperature, 50 °C; autosampler temperature, 40 °C; flow rate, 0.3 ml/min; drying/shielding gas temperature, 350/400 °C; nebulizer gas pressure, 20 psi; skimmer voltage, 60 V, octopole voltage, 750 V; capillary voltage, 4000 V; fragmentor voltage, 150 V. Notation: 1 ISI20, 2 ISI19, 3 ISIA18, 4 ISIA17