Figure 2. Reducing Adar levels does not alter sleep homeostasis.

(a and b) Representative sleep profiles (a) and total daily sleep (b) for Adar^hyp and sibling control animals (females; Adar^hyp (n=93); control (n=95)). (c and d) Representative sleep profiles during baseline, deprivation (red bar; ZT20–24) and recovery periods for sibling control (c) and Adar^hyp animals (d). (e and f) Quantification of sleep lost during deprivation period (e) and recovered the next morning from ZT0–6 (f). (g) Total sleep each day from ZT0–6. Sleep returns to baseline after 1 day of recovery. (In c–g: Adar^hyp (n=90); control (n=95)). In this figure, control refers to siblings of Adar^hyp animals outcrossed into a w¹¹¹⁸ genetic background. Females were used for all sleep homoeostasis experiments.