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. 2016 Feb 3;10:14. doi: 10.3389/fncel.2016.00014

Figure 4.

Figure 4

BID deficiency does not affect infarct formation or improves functional outcome after tMCAO. (A) Representative cresyl violet stained coronal sections of brains from BID-KO mice and WT mice. IF: Infarct. (B) Direct infarct volume estimations showed no significant difference in infarct volume between BID-KO mice and WT mice (p = 0.45, non-paired t-test). (C) This was also true for the rostrocaudale distribution analyses (p = 0.45, n = 6–7 in each group, mean ± SD). (D) To evaluate the neurodeficit of mice we applied a scoring system from 0–4. We did not see a difference either before or after reperfusion (p = 0.73), just as no difference was observed between BID-KO mice and WT mice at any of the two time points (p = 0.52, n = 6–7 in each group, 2-way ANOVA, mean ± SD). (E) Mice spent significantly less time on the vertical rope 24 h following reperfusion compared to before surgery (#p = 0.013), however, there was no difference between the two groups of mice at any of the time points (p = 0.29, n = 6–7 in each group, 2-way ANOVA, mean ± SD).