Skip to main content
. 2015 Jul 28;10(2):460–477. doi: 10.1038/ismej.2015.127

Table 1. Selection of significant upregulated genes when compared with germ-free mice.

Implantation Genes Fold change Description
Conventionalized Igj 468.0 Ig chain linker
  Trpv6 18.8 Calcium channel
  Ly6e 13.7 Proliferation of lymphocytes
  Reg3b 12.0 Antimicrobial peptide
  Ifi27l2a/Ifi47/Ifi44 11.9/8.3/6.1 IFN-induced factors
  Ccl5 8.6 Chemokine
  Cd3d/Cd3g 7.1/5.8 CD3 chains
  H2-DMb1/H2-Aa/H2-Ab1/H2-DMa 7.1/7.0/6.4/5.9 CMH II
B. thetaiotaomicron Igj 207.0 Ig chain linker
  C1s 5.1 Complement subunit
  Cd3d/Cd3g 4.3/3.4 CD3 chains
  Ifitm1 4.2 IFN-induced factor
  Mcpt4/Mcpt2/Mcpt1 4.2/4.0/3.8 Mast cell proteases
  Trem2 3.6 Inflammatory receptor
  Ccl5 3.5 Chemokine
E. coli Igj 96.7 Ig chain linker
  Reg3b/Reg3g 63.3/12.9 Antimicrobial peptides
  S100g/Slc10a2 11.5/5.4 Solute transporters
  Mmp7 7.2 Matrix metalloproteinase
  Ifi47 4.7 IFN-induced factor
  Ido1 4.5 Tryptophan metabolism
  Tlr13 4.4 Pattern recognition receptor
  Cxcl9 3.8 Chemokine
R. gnavus Igj 33.0 Ig chain linker
  Cyp3a44/3c55/3a16/3a59 7.5/5.9/5.2/3.1 Cytochrome P450 members
  Reg1 3.8 Antimicrobial peptide
  Tlr13 3.7 Pattern recognition receptor
  Ido1 3.0 Tryptophan metabolism
R. intestinalis Igj 8.1 Ig chain linker
  Dbp/Tef 7.4/3.1 Circadian rhythm
  C1s 5.1 Complement subunit
  S100g/Slc2a5/Slc10a2 5.0/4.0/3.8 Solute transporters
  Trem2 3.6 Inflammatory receptor
  Cxcl12 3.5 Chemokine
  Mcpt4 3.3 Mast cell protease
  Esm1/Egfl7 3.3/3.3 Produced by endothelial cells
  Clec3b 3.2 Pattern recognition receptor
S. boulardii Tex14 6.3 Cell division
  C1s 5.2 Complement subunit
  Igj 4.5 Ig chain linker
  Esm1/Egfl7/Glycam1/Apln 4.4/3.3/3.1/1.9 Produced by endothelial cells
  Mcpt4 3.0 Mast cell protease
  Col1a2/18a1 1.8/1.6 Collagen subunits, linked to angiogenesis
C. albicans Igj 9.5 Ig chain linker
  Esm1 5.3 Produced by endothelial cells
  Trpv6 4.7 Calcium channel
  Mcpt4 4.7 Mast cell protease
  Col6a3/1a2/5a1/5a3/6a1 4.0/3.9/3.9/3.4/3.2 Collagen subunits
  Cd93 3.8 C-type lectin receptor on immune and endothelial cells
  Cxcl12 3.3 Chemokine
  Clec3b 3.3 Pattern recognition receptor