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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Trends Parasitol. 2015 Nov 10;32(2):144–156. doi: 10.1016/j.pt.2015.10.004

Figure 3.

Figure 3

Schematic representation of mRNA interactions with RNA editing substrate binding, RNA editing core and polyadenylation complexes, and the ribosome. The RNA editing substrate binding complex (RESC) consists of three modules: guide RNA binding (GRBC), RNA editing mediator (REMC) and polyadenylation mediator (PAMC). These modules have been implicated in gRNA stabilization, recruitment of RNA editing core and polyadenylation complexes, respectively [17]. Pre-edited mRNA is depicted in red, edited mRNA is shown in blue, and edited A/U-tailed mRNA is colored in orange. The A/U-tail enables mRNA binding to the small ribosomal subunit (SSU) while RNA editing substrates and complexes are predominantly associated with the large ribosomal subunit (LSU).