Table 2.

Components of the RNA editing substrate binding complex (RESC).

Name	Function	Motifs (Pfam)	Essential gene	Synonym	T. brucei Gene IDc	Refs.
Guide RNA Binding Complex (GRBC)
GRBC1	gRNA binding		yes	GAP2	Tb927.7.2570	[17,63–65]
GRBC2	gRNA binding		yes	GAP1	Tb927.2.3800	[17,63–65]
GRBC3			nob	MRB8620	Tb927.11.16860	[17,101]
GRBC4			yes	MRB5390	Tb11.02.5390	[17,102]
GRBC5			yes	MRB11870	Tb927.10.11870	[17,101]
GRBC6			yes	MRB3010	Tb927.5.3010	[17,103]
GRBC7			yes	MRB0880	Tb927.11.9140	[17,104]
RNA Editing Mediator Complex (REMC)
REMC1			yes	MRB10130	Tb927.10.10130	[17,101,104]
REMC2			yes	MRB1860	Tb927.2.1860	[17,104]
REMC3			yes	MRB800	Tb927.7.800	[17]
REMC4			nob	MRB8180	Tb927.8.8180	[17]
REMC5a			yes	MRB4160	Tb927.4.4160	[17,105]
REMC5Aa			yes	MRB8170	Tb927.8.8170	[17,105]
RGG2	processivity of editing	RRM	yes	RGG2	Tb927.10.10830	[67,106,107]
Polyadenylation Mediator Complex (PAMC)
PAMC1			yes	MRB10130	Tb927.10.10130	[17,104]
PAMC2			yes		Tb927.6.1200	[17]
PAMC3			no		Tb927.10.1730	[17]
PAMC4			yes		Tb927.1.3010	[17]

^aPossible gene duplication.

^bInferred from RNAi knockdown.

^cGene identification numbers are from TriTrypDB Kinetoplastid Genomics Resource (http://tritrypdb.org).