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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Cancer Res. 2015 Dec 16;76(3):572–581. doi: 10.1158/0008-5472.CAN-15-0671

Figure 3. HEATR1 scaffolding function regulates Akt phosphorylation and cell survival.

Figure 3

(A) Schematic diagram of WT and deletion mutants of HEATR1 used in the study. (B–C) Cells were transfected with indicated constructs. Precipitation reactions were conducted with S-protein agarose beads and subjected to western blotting. (D) Cells were transfected with indicated constructs. Western blotting was performed. (E) Cells were transfected as in (D) and gemcitabine sensitivity was examined. The data presented are mean ± SD (n=6). +P<0.05, ++ P<0.01 (Ctrl vs HEATR1 KD)