. 2016 Jan 13;23(3):R157–R171. doi: 10.1530/ERC-15-0369

Table 3.

Genes for which promoter methylation in serum or plasma has been shown to be prognostic in different cancer types

	Colorectal		Breast		Melanoma		Gastric	Prostate			Esopha-geal	Lung	Neuro-blastoma	Bladder
RASSF1A					Mori et al. (2005) ^a	Koyanagi et al. (2006) ^a	Balgkouranidou et al. (2015) ^b	Okegawa et al. (2010) ^a					Misawa et al. (2009) ^a
GSTP1			Sharma et al. (2010) ^a					Mahon et al. (2014) ^a	Okegawa et al. (2010) ^a	Bastian et al. (2005) ^a
APC1							Balgkouranidou et al. (2015) ^a	Okegawa et al. (2010) ^a			Hoffmann et al. (2009) ^a			Ellinger et al. (2008) ^a
ESR1			Martinez-Galan et al. (2014) ^a	Mirza et al. (2010) ^b	Mori et al. (2006) ^a
RARB2			Mirza et al. (2010) ^a		Mori et al. (2005) ^a	Koyanagi et al. (2006) ^a
SOX17			Fu et al. (2015) ^a				Balgkouranidou et al. (2015) ^a
STRATIFIN			Mirza et al. (2010) ^b									Ramirez et al. (2005) ^c
DAPK1	Wong et al. (2004) ^a										Hoffman et al. (2009) ^a
CDKN2A	Lecomte et al. (2002) ^a	Wong et al. (2004) ^a
PITX2			Gobel et al. (2011) ^a
PR			Mirza et al. (2010) ^b
BRCA1			Sharma et al. (2010) ^a
MGMT	Barault et al. (2015) ^c
RUNX3	Nishio et al. (2010) ^a
HLTF	Philipp et al. (2012) ^a
HPP1	Philipp et al. (2012) ^a
CDH1	Wong et al. (2004) ^a
MDR1								Okegawa et al. (2010) ^a
PTGS2								Okegawa et al. (2010) ^a
SRD5A2								Horning et al. (2015) ^a
CYP11A1								Horning et al. (2015) ^a
TIMP3							Yu et al. (2014) ^a
MINT2							Han et al. (2014) ^a
XAF1							Ling et al. (2013) ^a
AIM1					Hoshimoto et al. (2012) ^a
LINE-1					Hoshimoto et al. (2012) ^c
BRMS1												Balgkouranidou et al. (2014) ^a
DCR2													Yagyu et al. (2008) ^a
MSH2											Ling et al. (2012) ^a

Methylation of the gene has a negative impact on prognosis.

No impact of gene methylation on prognosis was observed.

Methylation of the gene has a positive impact on prognosis.