Table 4.
PI susceptibility assays of recombinant viruses.
| NL4-3 | rFS5929 | rFS5929R1 | rFS5929R1I47 | rFS5929R1I50 | rFS5929R1I47∕I50 | |
|---|---|---|---|---|---|---|
| DRV | 0.0057 ± 0.0006* | 0.0111 ± 0.0036 (1.9†) | >1 (>175.3) | >1 (>175.3) | 0.5528 ± 0.0722 (96.9) | 0.1162 ± 0.0149 (20.4) |
| APV | 0.0278 ± 0.0042 | 0.4440 ± 0.1263 (16.0) | >1 (>35.9) | >1 (>35.9) | >1 (>35.9) | >1 (>35.9) |
| LPV | 0.0182 ± 0.0011 | >1 (>54.9) | >1 (>54.9) | >1 (>54.9) | >1 (>54.9) | 0.9493 ± 0.0453 (52.1) |
| RTV | 0.0347 ± 0.0049 | >1 (>28.8) | >1 (>28.8) | >1 (>28.8) | >1 (>28.8) | >1 (28.8) |
| NFV | 0.0120 ± 0.0006 | >1 (>83.1) | >1 (>83.1) | >1 (>83.1) | >1 (>83.1) | >1 (>83.1) |
| TPV | 0.1368 ± 0.0119 | 0.0646 ± 0.0192 (0.5) | 0.0500 ± 0.0119 (0.4) | 0.0204 ± 0.0068 (0.1) | 0.2397 ± 0.0250 (1.8) | 0.1810 ± 0.0037 (1.3) |
| ATV | 0.0047 ± 0.0013 | 0.0481 ± 0.0129 (10.2) | 0.0178 ± 0.0039 (3.8) | 0.0490 ± 0.0109 (10.4) | 0.0489 ± 0.0143 (10.4) | 0.1350 ± 0.0236 (28.7) |
| SQV | 0.0203 ± 0.0077 | 0.3030 ± 0.0622 (14.9) | 0.2500 ± 0.0506 (12.3) | 0.2631 ± 0.0555 (13.0) | 0.1838 ± 0.0451 (9.1) | 0.2440 ± 0.0183 (12.0) |
*
IC50 (μM).
†
Fold changes from IC50 of HIV-1 NL4-3 are written in parentheses.