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. Author manuscript; available in PMC: 2017 Mar 11.
Published in final edited form as: Neuroscience. 2016 Jan 7;317:76–107. doi: 10.1016/j.neuroscience.2015.12.058

Figure 6. Potential roles of HSP60 and GAT3 with MaxiK channels.

Figure 6

A. MaxiK channel is present in mitochondria of cardiac and neuronal cells. However, its mechanism of translocation to mitochondria is not known. A hypothetical pathway is shown where TOM and TIM facilitate translocation of MaxiK channel to mitochondria. Since HSP60 immunoprecipitates with MaxiK channel, interacts with MaxiK channel in HEK293T and colocalizes with MaxiK channel in hippocampal primary neurons, it could be facilitating the refolding of MaxiK channel in the mitochondria. B. The interaction of MaxiK channel and GAT3 may indicate that MaxiK channel could be directly involved in GABAergic signaling. MaxiK channel and GAT3 are present in glia and their interaction could be playing a direct role in neuronal signaling.