Skip to main content
. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Acta Physiol (Oxf). 2015 Nov 11;216(3):358–375. doi: 10.1111/apha.12622

Figure 8.

Figure 8

Quantification of extravascular fibrin deposition in lung homogenates (A), and total protein concentration in bronchoalveolar lavage fluid (BALF; B) and CINC1 expression in BALF (C) on day 10 in LPAR1 mutant and wild type Wistar rat pups. In the LPAR1 experiments pups did not receive treatment. Wild type pups served as controls in RA (open bar) and hyperoxia (shaded bar) for LPAR1 mutant rat pups kept in RA (open bar) or hyperoxia (shaded bar). In the Ki16425 experiments, room air pups (open bars) were injected daily with DMSO or Ki16425 and O2 pups (shaded bars) were injected daily with DMSO or Ki16425: 5 mg kg−1 day−1 until 10 days of age. Values are expressed as mean ± SEM. *p < 0.05, **p < 0.01 and ***p < 0.001 versus own RA controls. †p < 0.05 versus age-matched O2-exposed control. LPAR1M = LPAR1M318R/M318R mutant rat; Ki = Ki16425. −: daily administration of solvent (DMSO) in Ki16425 experiments or wild type rat in LPAR1 mutant rat experiments. +: daily treatment with 5 mg kg−1 of Ki16425 or LPAR1 mutant rat, n=8-12 per group For both experimental models three independent experiments were performed for fibrin deposition, total protein measurement in BALF as a marker for vascular leakage and CINC1 expression in BALF.