. Author manuscript; available in PMC: 2016 Aug 1.

Published in final edited form as: J Rheumatol. 2016 Jan 15;43(2):282–288. doi: 10.3899/jrheum.150184

Table 2.

Association of LTL with incident RA risk by cohort^a

	Nurses’ Health Studies			Women’s Health Study			Meta-analysis
	Ca/Co	OR	95% CI	Ca/Co	OR	95% CI	OR	95% CI	p-het
Shortest tertile	51/195	1.00		25/76	1.00		1.00
Intermediate	85/191	1.76	1.17 – 2.64	17/84	0.59	0.29 – 1.19	1.06	0.36 – 3.09	0.008
Longest tertile	86/198	1.75	1.16 – 2.62	32/83	1.15	0.62 – 2.13	1.51	1.03 – 2.23	0.27
Per standard deviation^b		1.19	1.01 – 1.40		1.15	0.88 – 1.51	1.18	1.03 – 1.35	0.85
p-trend^c		0.03			0.30		0.02

Ca=cases; Co=controls; OR=odds ratio; CI=confidence interval

Unconditional logistic regression adjusted for matching factors: age (continuous), menopausal status/HT use at blood draw (premenopausal, postmenopausal-no HT, postmenopausal-current HT, unknown), cohort (only for NHS, NHSII),

Nurses’ Health Study LTL standard deviation = 0.26; Women’s Health Study LTL standard deviation = 0.71

Based on per standard deviation analysis