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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: J Rheumatol. 2016 Jan 15;43(2):282–288. doi: 10.3899/jrheum.150184

Table 4.

Association of LTL with incident RA risk by time since blood draw to diagnosis in the Nurses’ Health Studies and the Women’s Health Study combineda

< 4 years
4 - < 8 years
8+ years
Ca/Co OR 95% CI Ca/Co OR 95% CI Ca/Co OR 95% CI p-het
Shortest tertile 13/52 1.00 28/83 1.00 31/115 1.00
Intermediate 26/71 1.13 0.18 – 7.16 31/89 1.06 0.32 – 3.51 41/92 1.58 0.94 – 2.67
Longest tertile 34/80 1.78 0.83 – 3.80 29/78 1.21 0.64 – 2.29 51/105 1.78 1.08 – 2.95
Per standard deviationb 1.20 0.91 – 1.59 1.14 0.87 – 1.48 1.22 1.00 – 1.49
P-trendc 0.19 0.35 0.05 0.85

Ca=cases; Co=controls; OR=odds ratio; CI=confidence interval

a

Meta-analysis used to combine estimates from unconditional logistic regression adjusted for the same covariates listed in Table 2

b

Nurses’ Health Study LTL standard deviation = 0.26; Women’s Health Study LTL standard deviation = 0.71

c

Based on per standard deviation analysis