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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Trends Immunol. 2016 Jan 7;37(2):141–153. doi: 10.1016/j.it.2015.12.007
Combination ClinicalTrials.gov Identifier Combination ClinicalTrials.gov Identifier
Target therapy and checkpoint blockade Targeted Therapy and Cytokine Therapy
Dabrafenib+/Trametinib+lpilimumab (NCT01767454;NCT01940809;
NCT01673854;NCT02200562)
Vemurafenib+High-dose IL-2 (NCT01754376;
NCT01683188)
Nivolumab + Wunitinib,
Pazopanib, or Ipilimumab
(NCT01472081) Vemurafenib+IL-2 (infusional 96
hour)+IFN-α
(NCT01603212)
Dabrafenib+Trametinib
followed by
Ipilimumab+Nivolumab
or vice versa
(NCT02224781) Vemurafenib+Pegylated IFN (NCT01959633)
Vemurafenib+Anti−PD-Ll (NCT01656642) Nilotinib+ Peginterferon α2b (NCT01657604;
NCT01866553;

NCT02001818;
NCT01220648)
Dabrafenib+Trametinib+Anti−PD-1 (NCT02130466) Vemurafenib+High-dose IFN-α2b (NCT01943422)
Trametinib+/− Dabrafenib+Anti−PD-
   L1
(NCT02027961) Pegylated IFN-alpha 2B+ Dasatinib (NCT01725204;

NCT01872442)
Imatinib mesylate+lpilimumab (NCT01738139)
lpilimumab+Cetuximab+/− Intensity-
   Modulated Radiation Therapy
(NCT01935921)
Sunitinib +Nivolumab (NCT02400385)
Pembrolizumab +Axitinib in
   advanced RCC
(NCT02133742)
Dasatinib+lpilimumab (NCT01643278)
Targeted Therapy and Cytokine Therapy
Vemurafenib+Tumor-infiltrating
Lymphocytes
(NCT00338377; NCT01585415; CT01659151)
Dasatinib+DC vaccine (NCT01876212)
Vaccine-peptide derived from the
protein IDO (IDO Long)+lpilimumab+
vemurafenib)
(NCT02077114)
Cetuximab+ GVAX+ Cyclophosphamide (NCT00305760)