Table 1. Trial omissions, locomotor activity and shock reactivity in the Risky Decision-Making Task in males and females.

In the Risky Decision-Making Task (RDT) with the same shock magnitudes for all rats, females omitted significantly more than males and showed less locomotor activity than males. When shocks were adjusted for body weight, females still omitted significantly more trials than males. This difference in trial omissions was also observed across all doses of amphetamine. At the 1.0 and 1.5 mg/kg doses of amphetamine, females displayed significantly less locomotor activity during shock delivery than males. Finally, there was a significant sex X dose interaction on shock reactivity, such that females showed significantly less locomotor activity during shock delivery relative to males at the highest dose of amphetamine.

Session	% Omitted Trials	Locomotion (locomotor units/ITI)	Shock reactivity (locomotor units/shock)
Risky Decision-Making Task with equal shock magnitude
Male	3.4 (1.9)*	16.6 (1.7)*	2.6 (0.2)
Female	15.2 (2.5)*	11.3 (0.9)*	2.3 (0.3)
Risky Decision-Making Task with adjusted shocks
Male	0.3 (0.2)*	18.6 (2.7)	N/A
Female	10.1 (4.1)*	13.6 (2.5)	N/A
Amphetamine
Vehicle
Male	5.8 (4.5)	17.5 (2.9)	2.8 (0.3)
Female	18.0 (5.3)	14.2 (1.8)	2.1 (0.3)
0.3 mg/kg
Male	4.5 (3.2)*	21.2 (3.2)	2.5 (0.3)
Female	16.3 (4.4)*	17.2 (2.1)	2.2 (0.4)
1.0 mg/kg
Male	7.3 (3.6)*	23.8 (2.9)	2.5 (0.3)*
Female	31 (6.8)*	24.7 (4.0)	1.2 (0.3)*
1.5 mg/kg
Male	14.8 (3.4)*	25.8 (2.1)	2.1 (0.4)*
Female	66.8 (9.4)*	22.6 (2.4)	0.3 (0.2)*†

Asterisks indicate a significant difference between males and females.

A cross indicates a significant sex X dose interaction.