Figure 2.
Meta-analysis across ethnicities of the association of sCVD measures and SNPs in the 9p21 region. A linear regression assuming an additive model and controlling for age, gender, site of ascertainment, principal components, HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), triglycerides, BMI, hypertension status, diabetes status and current smoking was performed in each ethnic group as described above. The program METAL was used to conduct a fixed effect meta-analysis to combine estimated effects and standard errors from stratified analyses. The y-axis represents the –log10 of the p-value and the dotted line the Bonferroni corrected significance threshold.