Table 2.
SNPs with significant associations with sCVD in meta-analysis across ethnicities. Chr=Chromosone, Gene=Closest gene, P. Beta=published beta (ethnicity), H. P-value=Heterogeneity p-value. I2=Heterogeneity metric. The direction of effect in each ethnicity is also illustrated. P-values meeting Bonferroni correction are highlighted.
| SNP | Chr | Gene | P. Beta | EUA | CHN | AFA | HIS | Beta | P-value | I2 | H. P-value |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
CAC-D | |||||||||||
| rs1333049 | 9 | CDKN2A | 0.302 (EUA) | − | − | + | − | −0.189 | 3.83E-06 | 81.2 | 1.17E-03 |
| rs4977574 | 9 | CDKN2A | 0.254 (EUA) | + | + | − | + | 0.212 | 5.33E-07 | 71.2 | 1.52E-02 |
| rs9349379 | 6 | PHACTR1 | 0.200 (EUA) 0.140 (CHN) |
+ | + | + | + | 0.250 | 4.53E-07 | 0.0 | 7.52E-01 |
| rs1994016 | 15 | ADAMTS7 | 0.174 (EUA) | + | + | + | + | 0.186 | 8.44E-05 | 0.0 | 7.46E-01 |
|
CAC-C | |||||||||||
| rs1333049 | 9 | CDKN2A | 0.302 (EUA) | − | − | + | − | −0.218 | 2.42E-09 | 19.5 | 2.18E-04 |
| rs4977574 | 9 | CDKN2A | 0.254 (EUA) | + | + | + | + | 0.252 | 2.55E-11 | 11.2 | 1.05E-02 |
| rs9515203 | 13 | COL4A1 | 0.077 (EUA) | − | + | − | + | −0.149 | 2.07E-04 | 73.7 | 9.79E-03 |
| rs9349379 | 6 | PHACTR1 | 0.200 (EUA) 0.140 (CHN) |
+ | + | + | + | 0.242 | 4.45E-08 | 1.5 | 6.73E-01 |
|
IMT-C | |||||||||||
| rs216172 | 17 | SMG6 | 0.068 (EUA) | + | − | + | + | 0.012 | 8.58E-05 | 23.4 | 2.71E-01 |
|
IMT-I | |||||||||||
| rs10455872 | 6 | LPA | 0.225 (EUA) | + | + | + | + | 0.102 | 1.48E-05 | 0.0 | 3.13E-01 |
| rs2954029 | 8 | TRIB1 | 0.049 (EUA) | − | − | − | − | −0.029 | 4.03E-05 | 0.0 | 9.57E-01 |