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. 2016 Feb 3;6:20298. doi: 10.1038/srep20298

Figure 3. Altered resting state-functional connectivity in MwoA patients and the modulation effect of acupuncture treament (verum + sham).

Figure 3

(A) Brain regions showed reduced resting state-functional connectivity with the vlPAG in MwoA patients, compared to healthy controls. (B) Brain regions showed reduced resting state-functional connectivity with vlPAG is associated with increased headache intensity as indicated by VAS scores in MwoA patients. (C) Partial regression between headache intensity and rs-fc value in MwoA patients (controlled for disease duration, SAS and SDS). (D) Acupuncture treatment normalized impaired vlPAG resting state-functional connectivity in MwoA patients. (E) Brain regions showed overlap between A and C. (F) The Fisher-z value of the overlap rACC in healthy controls and MwoA patients before and after acupuncture treatment respectively (mean ± SE). L, left side; MwoA, migraine without aura; rACC, rostral anterior cingulate cortex; mPFC, medial prefrontal cortex; R, right side; VAS, visual analogue scale; vlPAG, ventrolateral periaqueductal gray.