Table 4. The vlPAG resting state functional connectivity in MwoA patients and the changes in different groups.

vlPAG resting state-functional connectivity difference between MwoA patients in baseline and healthy controls							Changes of vlPAG resting state-functional connectivity in MwoA patients due to acupuncture treatment (verum + sham)
Contrast	Voxels	Brain Region	MNI (x, y, z)			Z	Contrast	Voxels	Brain Region	MNI (x, y, z)			Z
HC>MwoA	297	L OFC	−3	63	−18	5.81	Post>Pre	408	L MCC	−3	27	24	3.51
		L mPFC	−6	54	−12	3.91			L mPFC	−9	51	−6	3.18
		L rACC	−12	48	3	2.84			L rACC	−12	51	9	3.63
		R mPFC	6	57	−9	3.41			R MCC	3	18	15	4.29
	196	L OFC	−36	21	−21	4.34			R rACC	3	39	15	3.31
MwoA>HC	236	Bilateral PAG	3	−30	−15	3.55	Pre >Post		No brain region above the threshold
Difference between acupuncture treatment group (AG) and WT group in the changes of vlPAG resting state-functional connectivity							Changes of vlPAG resting state-functional connectivity in MwoA patients in WT group
AG >WT	501	L MCC	0	27	12	4.11	Post>Pre		No brain region above the threshold
		L mPFC	−6	54	−6	3.24	Pre>Post	221	L Inf Parietal Lob	−39	−45	42	3.74
		L rACC	−12	51	6	3.98			L Precuneus	−33	−63	45	3.72
		R rACC	6	39	15	3.58			L Angular gyrus	−33	−57	39	3.29
WT>AG		No brain region above the threshold

AG, acupuncture treatment group; L, left side; MCC, middle cingulate cortex; mPFC, medial prefrontal cortex; MwoA, migraine without aura; OFC, orbitofrontal cortex; rACC, rostral anterior cingulate cortex; R, right side; SMA, supplementary motor area; VA, verum acupuncture; VAS, visual analogue scale; vlPAG, ventrolateral periaqueductal gray; WT, waiting-list.