Table 5. The association between vlPAG resting state-functional connectivity and VAS.

Association between baseline VAS and baseline vlPAG resting state-functional connectivity in all MwoA patients							Association between VAS changes and vlPAG resting state-functional connectivity changes due to acupuncture treatment (verum + sham)
Contrast	Voxels	Brain Region	MNI (x, y, z)			Z	Contrast	Voxels	Brain Region	MNI (x, y, z)			Z
Negative	226	L mPFC/rACC	−6	54	−3	3.73	Negative	523	L MCC/rACC	−12	36	21	3.13
									L Sup Frontal gyrus	−24	42	27	3.77
									R MCC/rACC	15	48	21	3.88
									R SMA/preSMA	12	9	66	4.21
									R Mid Frontal gyrus	27	42	27	3.76
								296	L Putamen	−18	15	0	4.71
									L Caudate	−9	0	15	4.57
									L Thalamus	−15	−12	9	3.57
								300	L Cerebellum	−9	−57	−54	4.25
Positive	No brain region above the threshold						Positive	No brain region above the threshold

L, left side; MCC, middle cingulate cortex; mPFC, medial prefrontal cortex; MwoA, migraine without aura; rACC, rostral anterior cingulate cortex; R, right side; SMA, supplementary motor area; VAS, visual analogue scale; vlPAG, ventrolateral periaqueductal gray.