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. 2016 Feb 3;10:13. doi: 10.3389/fncel.2016.00013

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Copyright © 2016 Du, Kiyoshi, Wang, Wang, Ma, Alford, Zhong, Wan, Chen, Lloyd, Bryan and Zhou.

and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of astrocyte K⁺ channels in TREK-1, TWIK-1 single, and TWIK-1/TREK-1 double gene knockout mice. (A) Schematic illustrations of genetic deletion of four transmembrane domains, including two pore-forming regions, in TREK-1 knockout (TREK-1^−/−, upper), and TWIK-1 knockout (TWIK-1^−/−, lower) mice. (B) PCR genotyping confirmation of successful genetic knockout of the targeted genes in TWIK-1^−/−, TREK-1^−/−, and TWIK-1/TREK-1 double knockout (TWIK-1^−/−/TREK-1^−/−) mice. (C) The relative quantity of mRNA of K⁺ channels in freshly dissociated mature astrocytes. The results were examined from wild type (WT), TWIK-1^−/−, TREK-^1−/−, and TWIK-1^−/−/TREK-1^−/− astrocytes using qRT-PCR.