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. 2016 Feb 3;6:20033. doi: 10.1038/srep20033

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Copyright © 2016, Macmillan Publishers Limited

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The representative current traces showing the depressive effect of 5-HT (40 μM) (a1) and DOI (20 μM) (b1) on GABA currents, which was recovered after washout. (a2) and (b2) showed the time course of GABA currents when 5-HT and DOI were applied. (c), Representative traces showing no effect of α-methylserotonin (30 μM) on GABA currents. (d), Quantification data showing the reduction of GABA currents by 5-HT (n = 5), DOI (n = 10) and α-methylserotonin (n = 6). The deceasing effect was largely attenuated by ketanserin (40 μM, a selective 5-HT_2A/C receptor antagonist) (n = 4). **p <0.01. NS, no significant.