Figure 1. The mean cumulative excretion of radioactivity in the excreta of swine (n = 4), broilers (n = 6), carp (n = 6), and rats (n = 6) after a single oral administration of 5 mg/kg b. w ³ H-ADP for 14 d.

The excreta were collected in the period of 6, 12, and 24 h on day 1, and afterwards, intermittently in the period of 24 h up to 14 d after dosing. The samples from the individual animals were pooled from 0 to 6 h, 6 h to 1 d, 1 to 3 d, 3 to 7d, and 7 to 14 d post-dose, respectively. The cumulative recovery was expressed as percentage of the total oral dose. During the 14-day collection period, a total of more than 94% of the radioactive dose were recovered in the four species. The peak excretion occurred during 0–6 h, followed by a slow elimination. ADP-derived radioactivity was eliminated rapidly from broilers and relatively slowly from carp. In swine and rats, the urine excretion was the primary route for elimination, making up approximately 78% of the dose. The feces were the secondary route of excretion which cleared approximately 18% of the dose.