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. 2016 Feb 3;6:20559. doi: 10.1038/srep20559

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(A) Gross morphology of liver. Low dose: 1 × 10¹⁰ viral particles/ml; high dose: 3 × 10¹⁰viral particles/ml. (B) H&E staining in liver sections. A representative image from low dose treatment group is shown. Arrows indicate regions of coagulated hepatocyte necrosis. Scale bar: 200 μm. (C) Gross morphology of spleen (top) and the measurement of spleen weight (bottom). (D) Serum measurements of total or direct bilirubin, ALT, and total BA in low dose groups. (E) qPCR of liver Bcl2, Shp, H19, F4/80 expression in low dose groups. Data are represented as mean ± SD in all panels except (A,B) *P < 0.05 vs. GFP; ^¥P < 0.05 vs. Bcl2. (F) qPCR of gene expression in primary hepatocytes transduced with Bcl2. *P < 0.01 vs. GFP. (G) Immunohistochemistry of BCL2 and HNF4α protein localization in Bcl2 overexpressed mouse liver.