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. 2016 Jan 28;7:10548. doi: 10.1038/ncomms10548

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(a) Efficiency of Cas9-mediated RLL-EGFP knock-in in rabbit embryos. Left panel: effects of SCR7. Right panel: effects of RS-1 or RAD51 mRNA. (b) Effects of optimized RS-1 treatment (7.5 μM) on knock-in to CFTR and ApoAI loci in rabbit embryos versus control group (0 μM RS-1). Left panel: Cas9-mediated knock-in of CFTRdelF508 mutation to rabbit CFTR. Right panel: TALEN-mediated knock-in of hApoAII to rbApoAI. NS, not significantly different.