Figure 4. Increased feeding efficiency in MC3R^hDM/hDM mice.

Feeding efficiency (the ratio of body weight to energy intake (g Kcal⁻¹) × 20) was determined in female MC3R^hWT/hWT (open bars) and MC3R^hDM/hDM (closed bars) mice during (a) 5 weeks of chow diet feeding or (b) 7 weeks of high-fat-diet feeding. (c) For the high-fat pair-feeding study, the daily energy intake (11.83 Kcal per day) of 7- to 8-week-old female high-fat-fed MC3R^hWT/hWT mice (n=7) was supplied to the age matched female high-fat-fed MC3R^hDM/hDM mice (n=5), and their body weight change was monitored weekly. (d,e) Body composition of MC3R^hWT/hWT and MC3R^hDM/hDM mice was determined immediately after the end of pair-feeding period at age 12–13 weeks. Data are represented as mean±s.e.m. *P<0.05 and **P<0.01 MC3R^hDM/hDM versus MC3R^hWT/hWT mice. Groups were compared by Student's t-tests (two-tailed) (a,b,d and e) and two-way analysis of variance followed by Bonferroni post-tests (c).